H4C12

Across TCGA pan-cancer cohorts, H4C12 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated H4C12 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher H4C12 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated H4C12 expression acts as an unfavorable survival marker.

LUSC, DLBC, and COAD are the cancer types where H4C12 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	All	0.079	0.792	<.001	36	view →
DLBC	OS	Median	II,III,IV	0.172	0.949	<.001	30	view →
COAD	OS	Median	All	0.172	0.870	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

H4C12–LUSC (DFS)

Open the LUSC breakdown →