H4C1

Across TCGA patient cohorts, H4C1 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,401 significant associations in total. GBM shows the largest number of these associations.

The most reproducible H4C1-associated proteins across cancer lineages are SMC2, SMC4, and RFC2. Each is linked with H4C1 in more than 6 cancer types. Because this analysis shows association rather than direction, both H4C1-to-partner and partner-to-H4C1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, H4C1 versus SMC2 in GBM, with a Pearson correlation of 0.73.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (H4C1→partner) and Y-score (partner→H4C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SMC2 →	+0.723	+1.497	<.001	<.001	3	7
GBM	SMC4 →	+0.728	+1.442	<.001	<.001	3	7
GBM	RFC2 →	+0.355	+0.952	<.001	<.001	3	6
UCEC	RRM1 →	+0.667	+1.769	<.001	<.001	3	6
LUAD	RRM2 →	+0.848	+0.928	<.001	<.001	3	6
LUAD	CDC20_T70 →	+1.074	+0.867	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,401 associations by consensus.

H4C1 vs SMC2 — GBM

Explore this scatter interactively →