H3P41

Across TCGA pan-cancer cohorts, H3P41 RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated H3P41 data layer.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher H3P41 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated H3P41 expression acts as an unfavorable survival marker, although some lineages such as THYM show a favorable association.

BLCA, COAD, and MESO are the cancer types where H3P41 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Tertile	III,IV	0.209	0.556	<.001	99	view →
COAD	OS	Tertile	III,IV	0.163	0.791	.004	66	view →
MESO	DFS	Tertile	All	0.050	0.397	<.001	54	view →
STAD	DFS	Quartile	All	0.287	0.570	<.001	42	view →
BRCA	DFS	Tertile	All	0.140	1.000	.001	36	view →
CHOL	DFS	Tertile	All	0.037	0.486	.001	18	view →
ACC	OS	Tertile	II,III,IV	0.187	0.610	.020	18	view →
PCPG	DFS	Tertile	All	0.535	0.924	.002	18	view →
UCEC	DFS	Tertile	IV	0.292	0.718	.021	18	view →
DLBC	OS	Tertile	All	0.406	0.809	.010	12	view →
THYM	DFS	Tertile	III,IV	1.000	0.535	.025	8	view →
HNSC	DFS	Tertile	All	0.546	0.718	.035	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

H3P41–BLCA (DFS)

Open the BLCA breakdown →