H3P36

Across TCGA pan-cancer cohorts, H3P36 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated H3P36 data layer.

The strongest signal is observed in thyroid carcinoma (THCA), where higher H3P36 RNA is associated with better overall survival. In most high-consensus cancer types, elevated H3P36 expression acts as an unfavorable survival marker, although some lineages such as THCA and CESC show a favorable association.

THCA, UVM, and CESC are the cancer types where H3P36 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Tertile	All	1.000	0.870	<.001	113	view →
UVM	OS	Quartile	All	0.424	0.785	<.001	110	view →
CESC	OS	Tertile	All	0.908	0.701	<.001	64	view →
HNSC	OS	Quartile	III,IV	0.733	0.306	<.001	57	view →
SKCM	OS	Median	IV	0.836	0.260	<.001	35	view →
STAD	OS	Median	All	0.620	0.748	.002	33	view →
SARC	DFS	Quartile	All	0.483	0.681	.001	24	view →
LIHC	OS	Median	III,IV	0.458	0.736	.006	17	view →
PAAD	OS	Median	III,IV	0.629	1.000	.022	15	view →
ACC	DFS	Tertile	All	0.304	0.623	.016	15	view →
PRAD	DFS	Quartile	All	0.963	0.895	.005	12	view →
GBM	DFS	Quartile	All	0.488	0.178	.002	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

H3P36–THCA (OS)

Open the THCA breakdown →