H3P36

Across TCGA pan-cancer cohorts, H3P36 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of H3P36’s most consistent transcriptional readouts.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where H3P36 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types H3P36 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

UCEC, BRCA, and BLCA are the cancer types where H3P36 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in H3P36 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
UCEC	All	All	+0.686	.002	6	view →
BRCA	All	III,IV	+0.516	<.001	6	view →
BLCA	All	III,IV	+0.493	.015	6	view →
LIHC	Male	All	+0.236	<.001	6	view →
CHOL	All	All	+0.578	<.001	4	view →
COAD	All	II,III,IV	+0.468	.011	4	view →
KICH	All	All	−0.468	<.001	4	view →
STAD	Female	All	+0.662	.029	2	view →
LUSC	Female	All	+0.468	.010	2	view →
THCA	Male	All	+0.400	.040	1	view →
LUAD	All	All	+0.385	.007	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

H3P36–UCEC

Open the UCEC breakdown →