H3P34

Across TCGA pan-cancer cohorts, H3P34 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of H3P34’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where H3P34 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types H3P34 is over-expressed in tumor.

KICH and BRCA are the cancer types where H3P34 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in H3P34 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	All	+0.145	.002	4	view →
BRCA	All	All	+0.012	.033	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

H3P34–KICH

Open the KICH breakdown →