H3P33

Across TCGA pan-cancer cohorts, H3P33 RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated H3P33 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher H3P33 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated H3P33 expression acts as an unfavorable survival marker, although some lineages such as LAML and ACC show a favorable association.

KIRC, STAD, and UVM are the cancer types where H3P33 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	II,III,IV	0.423	0.557	.018	68	view →
STAD	DFS	Quartile	IV	0.181	0.549	.001	18	view →
UVM	DFS	Tertile	III,IV	0.079	0.674	.020	18	view →
COAD	OS	Tertile	IV	0.229	0.682	.003	18	view →
LUAD	DFS	Tertile	IV	0.215	0.634	.015	18	view →
READ	OS	Tertile	III,IV	0.242	0.794	<.001	18	view →
LIHC	DFS	Tertile	All	0.349	0.570	.001	18	view →
LAML	DFS	Tertile	All	0.595	0.366	.024	10	view →
BLCA	OS	Tertile	IV	0.419	0.626	.016	9	view →
THCA	DFS	Tertile	IV	0.488	0.791	.033	9	view →
ACC	DFS	Tertile	IV	0.921	0.271	.016	9	view →
ESCA	DFS	Median	All	0.330	0.901	.013	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

H3P33–KIRC (OS)

Open the KIRC breakdown →