H3P33

Across TCGA pan-cancer cohorts, H3P33 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of H3P33’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where H3P33 RNA is repressed in tumor relative to normal tissue. In most cancer types H3P33 is over-expressed in tumor, although a few such as BRCA and KIRP show the opposite, repressed pattern.

BRCA, KIRP, and LIHC are the cancer types where H3P33 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in H3P33 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	III,IV	−0.091	.002	2	view →
KIRP	All	All	−0.027	.022	2	view →
LIHC	Female	II,III,IV	+0.055	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

H3P33–BRCA

Open the BRCA breakdown →