H3P18

Across TCGA pan-cancer cohorts, H3P18 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated H3P18 data layer.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher H3P18 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated H3P18 expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

BLCA, UVM, and CESC are the cancer types where H3P18 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Tertile	III,IV	0.306	0.666	<.001	114	view →
UVM	OS	Tertile	II,III,IV	0.303	0.735	<.001	84	view →
CESC	OS	Tertile	IV	0.091	0.593	<.001	54	view →
LUAD	DFS	Tertile	All	0.938	0.630	.015	48	view →
HNSC	OS	Tertile	II,III,IV	0.540	0.726	.019	42	view →
BRCA	DFS	Tertile	All	0.140	1.000	.001	36	view →
GBM	DFS	Tertile	All	0.502	0.229	<.001	24	view →
THYM	DFS	Tertile	III,IV	0.214	1.000	.008	20	view →
PAAD	OS	Tertile	II,III,IV	0.213	0.556	.014	18	view →
ESCA	DFS	Tertile	III,IV	0.124	0.455	<.001	18	view →
CHOL	OS	Tertile	All	0.155	0.725	.029	9	view →
LIHC	OS	Tertile	All	0.410	0.692	.031	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

H3P18–BLCA (OS)

Open the BLCA breakdown →