H3P15

Across TCGA pan-cancer cohorts, H3P15 RNA is linked to patient survival in 9 of 34 cancer types, making it the most broadly survival-associated H3P15 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher H3P15 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated H3P15 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

UVM, ACC, and KIRC are the cancer types where H3P15 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.071	0.746	<.001	54	view →
ACC	OS	Tertile	All	0.114	0.892	<.001	54	view →
KIRC	OS	Tertile	All	0.487	0.657	<.001	51	view →
COAD	DFS	Tertile	II,III,IV	0.215	0.657	<.001	39	view →
OV	OS	Tertile	IV	0.059	0.759	.006	36	view →
SKCM	DFS	Tertile	IV	0.036	0.433	<.001	33	view →
HNSC	OS	Tertile	II,III,IV	0.903	0.736	.024	33	view →
PAAD	DFS	Tertile	All	0.182	0.479	.001	27	view →
LIHC	OS	Tertile	III,IV	0.059	0.738	<.001	18	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

H3P15–UVM (DFS)

Open the UVM breakdown →