H3P14

Across TCGA pan-cancer cohorts, H3P14 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated H3P14 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher H3P14 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated H3P14 expression acts as an unfavorable survival marker, although some lineages such as THCA and UCS show a favorable association.

ACC, THCA, and CESC are the cancer types where H3P14 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	All	0.200	0.750	<.001	85	view →
THCA	OS	Median	All	1.000	0.904	.002	29	view →
CESC	DFS	Tertile	II,III,IV	0.213	0.579	.006	24	view →
STAD	DFS	Median	II,III,IV	0.381	0.617	.005	21	view →
UCS	OS	Median	IV	0.693	0.262	.047	18	view →
KICH	OS	Median	II,III,IV	0.644	0.962	.004	14	view →
LIHC	OS	Quartile	All	0.620	0.820	.003	13	view →
GBM	DFS	Tertile	All	0.384	0.166	.004	11	view →
UVM	OS	Tertile	All	0.429	1.000	.007	11	view →
CHOL	DFS	Quartile	II,III,IV	0.177	0.573	.024	8	view →
ESCA	DFS	Median	III,IV	0.329	0.524	.021	7	view →
THYM	DFS	Tertile	II,III,IV	0.925	0.419	.009	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

H3P14–ACC (DFS)

Open the ACC breakdown →