H3P14

Across TCGA pan-cancer cohorts, H3P14 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of H3P14’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where H3P14 RNA is repressed in tumor relative to normal tissue. In most cancer types H3P14 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KICH, LIHC, and BRCA are the cancer types where H3P14 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in H3P14 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	II,III,IV	−0.929	<.001	9	view →
LIHC	Female	All	+0.507	<.001	8	view →
BRCA	All	III,IV	+1.059	<.001	6	view →
LUSC	Female	All	+0.782	<.001	5	view →
CHOL	All	All	+1.009	<.001	3	view →
BLCA	All	III,IV	+0.417	.014	3	view →
UCEC	All	All	+0.659	.005	2	view →
LUAD	All	All	+0.357	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

H3P14–KICH

Open the KICH breakdown →