H3P12

Across TCGA pan-cancer cohorts, H3P12 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated H3P12 data layer.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher H3P12 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated H3P12 expression acts as an unfavorable survival marker, although some lineages such as OV and LUAD show a favorable association.

BRCA, UCS, and READ are the cancer types where H3P12 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Tertile	II,III,IV	0.546	0.590	<.001	59	view →
UCS	OS	Tertile	IV	0.294	0.664	.012	36	view →
READ	DFS	Tertile	IV	0.304	0.695	.015	19	view →
OV	DFS	Median	IV	0.419	0.214	.005	18	view →
LUAD	OS	Quartile	II,III,IV	0.462	0.184	.009	18	view →
CESC	OS	Tertile	II,III,IV	0.876	0.695	.020	16	view →
KICH	DFS	Tertile	II,III,IV	0.614	0.880	.030	15	view →
UVM	OS	Tertile	All	0.372	0.725	.009	12	view →
BLCA	DFS	Tertile	IV	0.712	0.348	.012	9	view →
LUSC	OS	Quartile	II,III,IV	0.628	0.759	.023	9	view →
ESCA	OS	Quartile	III,IV	0.766	0.525	.009	6	view →
ACC	OS	Tertile	All	0.254	0.751	.016	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

H3P12–BRCA (OS)

Open the BRCA breakdown →