H3P12

Across TCGA pan-cancer cohorts, H3P12 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of H3P12’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where H3P12 RNA is repressed in tumor relative to normal tissue. In most cancer types H3P12 is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

KICH, BRCA, and COAD are the cancer types where H3P12 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in H3P12 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	All	−0.065	.016	4	view →
BRCA	All	All	+0.054	.002	4	view →
COAD	All	III,IV	−0.144	.027	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

H3P12–KICH

Open the KICH breakdown →