H3C8

Across TCGA patient cohorts, H3C8 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H3C8-associated genes across cancer lineages are p62 Lck ligand, Ku80, and Rab11. Each is linked with H3C8 in more than 1 cancer types. Because this analysis shows association rather than direction, both H3C8-to-partner and partner-to-H3C8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by H3C8-low versus H3C8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H3C8→partner) and Y-score (partner→H3C8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.575	+3.009	<.001	.019	3	2
UCEC	Ku80 →	+0.272	+2.183	.028	.035	3	1
UCEC	Rab11 →	-0.223	-3.321	.003	.010	3	1
UCEC	4E-BP1 →	+0.375	+2.837	.008	.035	3	1
UCEC	ARID1A →	-0.267	-3.314	.005	.010	2	1
UCEC	Di-Ras3 →	-0.186	-3.000	.016	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

p62 Lck ligand by H3C8 expression — UCEC

Explore this box plot interactively →