H3C8

Across TCGA pan-cancer cohorts, H3C8 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of H3C8’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where H3C8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types H3C8 is over-expressed in tumor, although a few such as THCA and PRAD show the opposite, repressed pattern.

HNSC, BLCA, and KIRC are the cancer types where H3C8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in H3C8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.008	<.001	12	view →
BLCA	All	All	+1.156	.002	9	view →
KIRC	Male	All	+0.351	<.001	9	view →
BRCA	Female	II,III,IV	+0.980	<.001	8	view →
LUSC	Male	All	+0.908	<.001	8	view →
STAD	All	II,III,IV	+0.630	.002	8	view →
LUAD	All	All	+0.579	<.001	8	view →
UCEC	All	All	+0.734	<.001	6	view →
KIRP	Male	All	+0.314	<.001	6	view →
LIHC	All	All	+0.177	<.001	6	view →
KICH	All	All	+0.355	.001	5	view →
THCA	All	IV	−0.504	.008	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

H3C8–HNSC

Open the HNSC breakdown →