H3C8

Across TCGA cell cohorts, H3C8 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,793 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible H3C8-associated GO terms across cancer lineages are Regulation of mRNA 3'-end processing, Mitochondrial electron transport, succinate to ubiquinone, and Autophagy of mitochondrion. Each is linked with H3C8 in more than 6 cancer types. Because this analysis shows association rather than direction, both H3C8-to-partner and partner-to-H3C8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mRNA 3'-end processing grouped by H3C8-low versus H3C8-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (H3C8→partner) and Y-score (partner→H3C8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of mRNA 3'-end processing →	+0.107	+0.731	.001	.001	3	7
LUNG_SCLC	Mitochondrial electron transport, succinate to ubiquinone →	+0.093	+0.753	.001	.001	3	6
BREAST	Autophagy of mitochondrion →	+0.045	+0.849	.003	.003	3	6
LARGE_INTESTINE	Short-term memory →	+0.216	+0.464	.001	.002	3	6
BONE	Innate immune response in mucosa →	-0.163	-0.412	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway →	-0.057	-0.632	.005	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,793 associations by consensus.

Regulation of mRNA 3'-end processing by H3C8 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →