H3C13

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, H3C13 mutation is significantly associated with the RNA expression of many other genes, with 96 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible H3C13-associated genes across cancer lineages are DUX4L47, NKAIN1P2, and OR8V1P. Each is linked with H3C13 in more than 1 cancer types. Because this analysis shows association rather than direction, both H3C13-to-partner and partner-to-H3C13 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H3C13→partner) and Y-score (partner→H3C13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BLCADUX4L47 →+0.636+5.685<.001.00332
BLCANKAIN1P2 →+0.080+6.814<.001<.00132
BLCAOR8V1P →+0.056+8.051<.001<.00132
BLCARPS4XP15 →+0.053+5.329.005.00632
LUSCRNU6-461P →+0.195+5.751<.001<.00132
THCARNU6-961P →+0.329+7.962<.001.00731
Each partner links to its Q-omics profile. Showing the 6 strongest of 96 associations by consensus.

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