Across TCGA patient cohorts, H3-5 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,024 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H3-5-associated GO terms across cancer lineages are Transcription by RNA polymerase III, Regulation of stem cell population maintenance, and Positive regulation of mRNA metabolic process. Each is linked with H3-5 in more than 24 cancer types. Because this analysis shows association rather than direction, both H3-5-to-partner and partner-to-H3-5 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (H3-5→partner) and Y-score (partner→H3-5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Transcription by RNA polymerase III →	+0.086	+2.357	<.001	<.001	3	25
THYM	Regulation of stem cell population maintenance →	+0.056	+0.543	<.001	<.001	2	24
ESCA	Positive regulation of mRNA metabolic process →	+0.033	+0.237	.004	.004	2	24
STAD	Regulation of translational initiation →	+0.053	+0.314	<.001	<.001	3	23
STAD	Nuclear-transcribed mRNA catabolic process →	+0.043	+0.203	<.001	.002	3	22
STAD	rRNA metabolic process →	+0.038	+0.223	<.001	<.001	3	22

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,024 associations by consensus.

Exploration

H3-5 survival (RNA) · tumor vs normal (RNA) · all H3-5 data types