Across TCGA patient cohorts, H3-5 mutation is significantly associated with the RNA expression of many other genes, with 331 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H3-5-associated genes across cancer lineages are IGKV1-37, RPS15AP3, and LINC02438. Each is linked with H3-5 in more than 1 cancer types. Because this analysis shows association rather than direction, both H3-5-to-partner and partner-to-H3-5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H3-5→partner) and Y-score (partner→H3-5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	IGKV1-37 →	+0.537	+2.678	<.001	.004	3	2
BLCA	RPS15AP3 →	+0.245	+5.788	<.001	.003	3	2
UCEC	LINC02438 →	+0.635	+3.584	<.001	.002	3	2
SKCM	RNA5SP500 →	+0.120	+4.219	<.001	.006	3	2
SKCM	MIR6839 →	+0.099	+3.993	<.001	.008	3	1
UCEC	MIR7702 →	+0.191	+3.973	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 331 associations by consensus.

Exploration

H3-5 survival (RNA) · tumor vs normal (RNA) · all H3-5 data types