Across TCGA patient cohorts, H3-5 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H3-5-associated genes across cancer lineages are ERK2, Rictor_pT1135, and TIGAR. Each is linked with H3-5 in more than 1 cancer types. Because this analysis shows association rather than direction, both H3-5-to-partner and partner-to-H3-5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H3-5→partner) and Y-score (partner→H3-5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.215	+3.000	.010	.036	3	1
UCEC	Rictor_pT1135 →	-0.089	-2.115	.047	.019	3	1
UCEC	TIGAR →	+0.140	+2.142	.036	.010	3	1
UCEC	Bax →	+0.259	+2.115	.013	.019	3	1
UCEC	cIAP →	+0.163	+1.884	.006	.030	3	1
UCEC	Annexin-1 →	+0.727	+2.807	.001	.003	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

H3-5 survival (RNA) · tumor vs normal (RNA) · all H3-5 data types