Across TCGA cell cohorts, H3-5 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible H3-5-associated genes across cancer lineages are MAGEB4, OR10W1, and DYDC1. Each is linked with H3-5 in more than 1 cancer types. Because this analysis shows association rather than direction, both H3-5-to-partner and partner-to-H3-5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H3-5→partner) and Y-score (partner→H3-5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.012	+5.415	.009	.004	3	1
LARGE_INTESTINE	OR10W1 →	+0.019	+4.977	<.001	.007	3	1
LUNG_NSCLC_LUAD	DYDC1 →	+0.041	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR4F5 →	+0.012	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration

H3-5 survival (RNA) · tumor vs normal (RNA) · all H3-5 data types