H3-4

Across TCGA pan-cancer cohorts, H3-4 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated H3-4 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher H3-4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated H3-4 expression acts as an unfavorable survival marker.

COAD and ACC are the cancer types where H3-4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	III,IV	0.082	0.792	<.001	18	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

H3-4–COAD (OS)

Open the COAD breakdown →