H3-3A

Across TCGA patient cohorts, H3-3A RNA expression is significantly associated with the protein abundance of many other proteins, with 13,680 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible H3-3A-associated proteins across cancer lineages are PARP1, RPRD2, and C1orf35. Each is linked with H3-3A in more than 7 cancer types. Because this analysis shows association rather than direction, both H3-3A-to-partner and partner-to-H3-3A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, H3-3A versus PARP1 in HNSC, with a Pearson correlation of 0.62.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (H3-3A→partner) and Y-score (partner→H3-3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PARP1 →	+0.458	+0.448	<.001	<.001	3	8
HNSC	RPRD2 →	+0.279	+0.389	<.001	<.001	3	7
BRCA	C1orf35 →	+0.447	+0.523	<.001	<.001	3	7
GBM	KDM1A →	+0.244	+0.289	<.001	<.001	3	7
HNSC	RCOR3 →	+0.502	+0.544	<.001	<.001	3	6
UCEC	POGK →	+0.303	+0.519	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,680 associations by consensus.

H3-3A vs PARP1 — HNSC

Explore this scatter interactively →