H3-3A

Across TCGA pan-cancer cohorts, H3-3A RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated H3-3A data layer compared with 4 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher H3-3A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated H3-3A expression acts as an unfavorable survival marker, although some lineages such as COAD and LAML show a favorable association.

ACC, KICH, and COAD are the cancer types where H3-3A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.208	0.684	<.001	88	view →
KICH	OS	Quartile	II,III,IV	0.687	1.000	.004	33	view →
COAD	OS	Tertile	IV	1.000	0.220	<.001	31	view →
LIHC	OS	Quartile	All	0.555	0.777	<.001	30	view →
UVM	DFS	Median	III,IV	0.208	0.740	.006	28	view →
LAML	DFS	Quartile	All	0.563	0.301	.009	24	view →
THCA	DFS	Tertile	All	0.931	0.755	<.001	23	view →
KIRP	OS	Median	IV	0.045	0.590	.025	21	view →
UCEC	DFS	Tertile	All	0.462	0.716	<.001	18	view →
GBM	DFS	Tertile	All	0.439	0.156	<.001	15	view →
LUSC	OS	Tertile	All	0.851	0.623	.009	15	view →
SKCM	OS	Median	IV	0.867	0.225	.001	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

H3-3A–ACC (DFS)

Open the ACC breakdown →