H3-3A

Across TCGA patient cohorts, H3-3A protein abundance is significantly associated with the RNA expression of many other genes, with 1,387 significant associations in total. GBM shows the largest number of these associations.

The most reproducible H3-3A-associated genes across cancer lineages are CD63, LANCL3, and S100A13. Each is linked with H3-3A in more than 1 cancer types. Because this analysis shows association rather than direction, both H3-3A-to-partner and partner-to-H3-3A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, H3-3A versus CD63 in GBM, with a Pearson correlation of 0.68.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H3-3A→partner) and Y-score (partner→H3-3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CD63 →	+0.905	+1.408	.006	.002	3	2
GBM	LANCL3 →	+1.393	+0.985	.008	.004	3	2
GBM	S100A13 →	+1.323	+0.671	<.001	.003	3	2
GBM	UBE2CP4 →	-0.485	-1.147	.004	<.001	3	2
GBM	NFKB1 →	+0.633	+1.508	<.001	<.001	3	2
CCRCC	CISH →	+1.165	+0.402	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,387 associations by consensus.

H3-3A vs CD63 — GBM

Explore this scatter interactively →