H3-3A

Across TCGA patient cohorts, H3-3A mutation is significantly associated with the RNA expression of many other genes, with 368 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible H3-3A-associated genes across cancer lineages are CFTRP1, MIR4268, and MTND4LP24. Each is linked with H3-3A in more than 2 cancer types. Because this analysis shows association rather than direction, both H3-3A-to-partner and partner-to-H3-3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFTRP1 grouped by H3-3A-low versus H3-3A-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H3-3A→partner) and Y-score (partner→H3-3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	CFTRP1 →	+1.244	+7.924	<.001	.008	3	3
BLCA	MIR4268 →	+0.458	+7.640	<.001	.009	3	2
CESC	MTND4LP24 →	+0.158	+7.164	<.001	<.001	3	2
CESC	MTND3P13 →	+0.259	+6.144	<.001	.001	3	2
LGG	MIR30E →	+0.246	+4.529	<.001	.009	3	2
LGG	RN7SKP245 →	+0.106	+4.679	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 368 associations by consensus.

CFTRP1 by H3-3A expression — LUSC

Explore this box plot interactively →