H3-3A

Across TCGA cell cohorts, H3-3A RNA expression is significantly associated with the go_rna of many other GO terms, with 5,750 significant associations in total. BONE shows the largest number of these associations.

The most reproducible H3-3A-associated GO terms across cancer lineages are Peptide antigen transport, Regulation of hemostasis, and Positive regulation of stem cell population maintenance. Each is linked with H3-3A in more than 12 cancer types. Because this analysis shows association rather than direction, both H3-3A-to-partner and partner-to-H3-3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Peptide antigen transport grouped by H3-3A-low versus H3-3A-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (H3-3A→partner) and Y-score (partner→H3-3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Peptide antigen transport →	-1.409	-0.995	<.001	<.001	3	13
SOFT_TISSUE	Regulation of hemostasis →	-0.234	-1.072	<.001	<.001	3	11
LUNG_SCLC	Positive regulation of stem cell population maintenance →	+0.130	+0.936	<.001	<.001	2	12
UPPER_AERODIGESTIVE_TRACT	Positive regulation of mitochondrial ATP synthesis coupled electron transport →	+0.120	+1.052	<.001	<.001	3	11
BONE	Rostrocaudal neural tube patterning →	+0.159	+1.006	<.001	<.001	3	11
SOFT_TISSUE	Cytoplasmic pattern recognition receptor signaling pathway →	-0.072	-0.737	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,750 associations by consensus.

Peptide antigen transport by H3-3A expression — BONE

Explore this box plot interactively →