H3-3A

Across TCGA cell cohorts, H3-3A mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible H3-3A-associated genes across cancer lineages are OR2M5, GML, and RXFP3. Each is linked with H3-3A in more than 1 cancer types. Because this analysis shows association rather than direction, both H3-3A-to-partner and partner-to-H3-3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2M5 grouped by H3-3A-low versus H3-3A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H3-3A→partner) and Y-score (partner→H3-3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR2M5 →	+0.029	+5.415	<.001	.004	3	1
BLOOD_Leukemia	GML →	+0.104	+4.152	<.001	.009	3	1
BLOOD_Leukemia	RXFP3 →	+0.013	+4.874	<.001	.002	3	1
BLOOD_Leukemia	IFNA10 →	+0.044	+4.539	<.001	.007	3	1
BLOOD_Leukemia	OR1D4 →	+0.023	+4.539	.006	.007	3	1
BLOOD_Leukemia	OR52E5 →	+0.012	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

OR2M5 by H3-3A expression — LARGE_INTESTINE

Explore this box plot interactively →