H3-3A

Across TCGA cell cohorts, H3-3A mutation is significantly associated with the mutation status of many other genes, with 361 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible H3-3A-associated genes across cancer lineages are MOGS, ST6GALNAC5, and MOCS1. Each is linked with H3-3A in more than 1 cancer types. Because this analysis shows association rather than direction, both H3-3A-to-partner and partner-to-H3-3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MOGS grouped by H3-3A-low versus H3-3A-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H3-3A→partner) and Y-score (partner→H3-3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MOGS →	+5.392	+5.392	.004	.004	1	2
UPPER_AERODIGESTIVE_TRACT	ST6GALNAC5 →	+5.392	+5.392	.004	.004	1	2
UPPER_AERODIGESTIVE_TRACT	MOCS1 →	+4.392	+4.954	.008	.008	1	2
UPPER_AERODIGESTIVE_TRACT	BMP15 →	+4.392	+4.954	.008	.008	1	2
UPPER_AERODIGESTIVE_TRACT	SLC34A1 →	+5.392	+5.392	.004	.004	1	2
UPPER_AERODIGESTIVE_TRACT	LRPPRC →	+5.392	+5.392	.004	.004	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 361 associations by consensus.

MOGS by H3-3A expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →