H3-2

Across TCGA patient cohorts, H3-2 protein abundance is significantly associated with the RNA expression of many other genes, with 6,110 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible H3-2-associated genes across cancer lineages are CYTH4, HCK, and AQP9. Each is linked with H3-2 in more than 2 cancer types. Because this analysis shows association rather than direction, both H3-2-to-partner and partner-to-H3-2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, H3-2 versus CYTH4 in HNSC, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H3-2→partner) and Y-score (partner→H3-2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CYTH4 →	+1.038	+0.783	<.001	<.001	3	3
HNSC	HCK →	+0.968	+0.763	.005	<.001	3	3
PDAC	AQP9 →	+1.464	+0.902	<.001	<.001	3	3
PDAC	RCN3 →	+0.620	+0.753	<.001	.001	3	3
LUAD	ADM →	+1.293	+0.725	.002	.005	3	3
COAD	VEGFC →	+0.780	+0.321	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,110 associations by consensus.

H3-2 vs CYTH4 — HNSC

Explore this scatter interactively →