H3-2

Across TCGA pan-cancer cohorts, H3-2 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated H3-2 data layer compared with 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher H3-2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated H3-2 expression acts as an unfavorable survival marker, although some lineages such as SKCM and PRAD show a favorable association.

UVM, THCA, and STAD are the cancer types where H3-2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.311	0.655	<.001	63	view →
THCA	DFS	Tertile	All	0.741	0.869	.008	54	view →
STAD	OS	Median	All	0.629	0.740	.007	31	view →
KICH	OS	Tertile	All	0.766	1.000	.012	30	view →
MESO	DFS	Median	III,IV	0.170	0.660	<.001	24	view →
COAD	DFS	Tertile	IV	0.314	0.542	.017	24	view →
THYM	DFS	Quartile	All	0.491	1.000	.002	22	view →
SKCM	DFS	Quartile	II,III,IV	0.636	0.460	.001	20	view →
PAAD	DFS	Median	All	0.188	0.384	.011	18	view →
KIRC	DFS	Median	III,IV	0.559	0.722	.014	15	view →
LUSC	OS	Quartile	All	0.334	0.488	.003	14	view →
CESC	DFS	Quartile	All	0.746	0.842	.021	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

H3-2–UVM (DFS)

Open the UVM breakdown →