H2BW2

Across TCGA pan-cancer cohorts, H2BW2 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated H2BW2 data layer compared with 16 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher H2BW2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated H2BW2 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, ESCA, and KICH are the cancer types where H2BW2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.156	0.751	<.001	48	view →
ESCA	OS	Median	All	0.198	0.872	.003	18	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
CESC	DFS	Median	III,IV	0.240	0.726	.015	6	view →
UCEC	DFS	Median	All	1.000	0.636	.043	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

H2BW2–HNSC (OS)

Open the HNSC breakdown →