H2BW2

Across TCGA pan-cancer cohorts, H2BW2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated H2BW2 data layer compared with 16 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher H2BW2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated H2BW2 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

UCEC, LUAD, and HNSC are the cancer types where H2BW2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	All	0.883	1.000	.035	4	view →
LUAD	DFS	Median	II,III,IV	0.784	0.333	.029	4	view →
HNSC	OS	Median	III,IV	1.000	0.946	.037	3	view →
PDAC	DFS	Tertile	All	0.853	0.659	.031	1	view →
LSCC	OS	Median	All	0.886	0.736	.027	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

H2BW2–UCEC (OS)

Open the UCEC breakdown →