H2BW1

Across TCGA patient cohorts, H2BW1 mutation is significantly associated with the RNA expression of many other genes, with 1,131 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H2BW1-associated genes across cancer lineages are RNU6-170P, MIR1343, and PLEKHH3. Each is linked with H2BW1 in more than 2 cancer types. Because this analysis shows association rather than direction, both H2BW1-to-partner and partner-to-H2BW1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-170P grouped by H2BW1-low versus H2BW1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2BW1→partner) and Y-score (partner→H2BW1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-170P →	+0.233	+4.754	<.001	.005	3	3
CESC	MIR1343 →	+0.540	+6.124	<.001	<.001	3	2
UCEC	PLEKHH3 →	+0.584	+3.711	.004	<.001	3	2
LUAD	MIR610 →	+0.357	+4.798	<.001	.006	3	2
LUAD	MIR4505 →	+1.083	+4.453	<.001	.006	3	2
COAD	TAS2R9 →	+0.074	+3.789	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,131 associations by consensus.

RNU6-170P by H2BW1 expression — HNSC

Explore this box plot interactively →