H2BW1

Across TCGA pan-cancer cohorts, H2BW1 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated H2BW1 data layer compared with 2 for mutation status.

The strongest signal is observed in small cell lung cancer (SCLC), where higher H2BW1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated H2BW1 expression acts as an unfavorable survival marker, although some lineages such as SCLC and LUSC show a favorable association.

SCLC, KICH, and KIRC are the cancer types where H2BW1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	DFS	Tertile	All	0.651	0.304	<.001	87	view →
KICH	OS	Tertile	All	0.082	0.877	<.001	78	view →
KIRC	OS	Quartile	II,III,IV	0.393	0.578	.002	72	view →
COAD	OS	Tertile	IV	0.197	0.703	<.001	57	view →
BLCA	DFS	Tertile	All	0.499	0.692	<.001	42	view →
DLBC	OS	Tertile	All	0.060	0.836	<.001	42	view →
SKCM	DFS	Tertile	III,IV	0.203	0.530	<.001	36	view →
MESO	OS	Tertile	IV	0.077	0.592	.019	27	view →
LUSC	OS	Tertile	II,III,IV	0.780	0.645	.010	16	view →
LUAD	DFS	Tertile	IV	0.671	0.893	.019	12	view →
ESCA	DFS	Median	All	0.202	0.434	<.001	12	view →
READ	DFS	Tertile	IV	0.343	0.666	.032	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

H2BW1–SCLC (DFS)

Open the SCLC breakdown →