H2BW1

Across TCGA patient cohorts, H2BW1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H2BW1-associated genes across cancer lineages are Ku80, MSH2, and PDCD4. Each is linked with H2BW1 in more than 1 cancer types. Because this analysis shows association rather than direction, both H2BW1-to-partner and partner-to-H2BW1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by H2BW1-low versus H2BW1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2BW1→partner) and Y-score (partner→H2BW1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.236	+2.472	.039	.011	3	1
UCEC	MSH2 →	-0.300	-2.990	.007	.036	3	1
UCEC	PDCD4 →	-0.815	-3.584	<.001	.002	3	1
UCEC	Stathmin →	+0.274	+3.026	<.001	.018	3	1
UCEC	Chk1_pS345 →	-0.174	-2.446	.009	.020	3	1
UCEC	C-Raf →	+0.150	+2.321	.030	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Ku80 by H2BW1 expression — UCEC

Explore this box plot interactively →