H2BW1

Across TCGA cell cohorts, H2BW1 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible H2BW1-associated genes across cancer lineages are TBX22, OR4F4, and OR52N4. Each is linked with H2BW1 in more than 1 cancer types. Because this analysis shows association rather than direction, both H2BW1-to-partner and partner-to-H2BW1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBX22 grouped by H2BW1-low versus H2BW1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2BW1→partner) and Y-score (partner→H2BW1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TBX22 →	+0.027	+4.369	<.001	.008	3	1
SOFT_TISSUE	OR4F4 →	+0.014	+5.169	<.001	<.001	3	1
SOFT_TISSUE	OR52N4 →	+0.079	+4.882	<.001	.001	3	1
SOFT_TISSUE	C9orf92 →	+0.144	+4.369	<.001	.008	3	1
SOFT_TISSUE	OR4A47 →	+0.009	+4.369	<.001	.008	3	1
LARGE_INTESTINE	TSHB →	+0.066	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

TBX22 by H2BW1 expression — SOFT_TISSUE

Explore this box plot interactively →