H2BS1

Across TCGA patient cohorts, H2BS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,216 significant associations in total. COAD shows the largest number of these associations.

The most reproducible H2BS1-associated GO terms across cancer lineages are Innate immune response in mucosa, Protein localization to CENP-A containing chromatin, and Negative regulation of megakaryocyte differentiation. Each is linked with H2BS1 in more than 11 cancer types. Because this analysis shows association rather than direction, both H2BS1-to-partner and partner-to-H2BS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Innate immune response in mucosa grouped by H2BS1-low versus H2BS1-high in OV.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (H2BS1→partner) and Y-score (partner→H2BS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	Innate immune response in mucosa →	+0.076	+0.383	<.001	<.001	3	12
ESCA	Protein localization to CENP-A containing chromatin →	+0.054	+0.412	<.001	<.001	3	11
ESCA	Negative regulation of megakaryocyte differentiation →	+0.054	+0.534	<.001	<.001	3	9
ESCA	Organ or tissue specific immune response →	+0.047	+0.467	<.001	<.001	3	8
ESCA	Protein localization to chromosome, centromeric region →	+0.047	+0.313	<.001	<.001	3	7
ESCA	Regulation of DNA-templated DNA replication initiation →	+0.080	+0.422	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,216 associations by consensus.

Innate immune response in mucosa by H2BS1 expression — OV

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