H2BS1

Across TCGA pan-cancer cohorts, H2BS1 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated H2BS1 data layer.

The strongest signal is observed in cholangiocarcinoma (CHOL), where higher H2BS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated H2BS1 expression acts as an unfavorable survival marker, although some lineages such as CESC and OV show a favorable association.

CHOL, CESC, and BLCA are the cancer types where H2BS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CHOL	OS	Tertile	All	0.024	0.675	<.001	90	view →
CESC	OS	Median	II,III,IV	0.942	0.762	.008	52	view →
BLCA	OS	Quartile	IV	0.347	0.635	<.001	48	view →
OV	DFS	Median	IV	0.627	0.298	<.001	44	view →
MESO	OS	Tertile	IV	0.218	0.710	.001	36	view →
LUSC	OS	Median	IV	0.255	0.851	.021	30	view →
UVM	DFS	Tertile	III,IV	0.075	0.682	<.001	27	view →
TGCT	DFS	Tertile	III,IV	0.017	0.923	.021	18	view →
KIRC	DFS	Tertile	III,IV	0.666	0.761	.031	15	view →
LIHC	OS	Tertile	III,IV	0.723	0.301	.012	15	view →
THCA	OS	Tertile	IV	0.579	1.000	<.001	12	view →
KICH	DFS	Tertile	II,III,IV	0.102	0.775	.025	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

H2BS1–CHOL (OS)

Open the CHOL breakdown →