H2BS1

Across TCGA cell cohorts, H2BS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,050 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible H2BS1-associated GO terms across cancer lineages are Negative regulation of autophagy, Vacuole organization, and Protein localization to CENP-A containing chromatin. Each is linked with H2BS1 in more than 9 cancer types. Because this analysis shows association rather than direction, both H2BS1-to-partner and partner-to-H2BS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of autophagy grouped by H2BS1-low versus H2BS1-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (H2BS1→partner) and Y-score (partner→H2BS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Negative regulation of autophagy →	+0.052	+0.942	<.001	.003	3	10
BLOOD_Lymphoma	Vacuole organization →	+0.039	+1.053	.001	<.001	3	10
CNS	Protein localization to CENP-A containing chromatin →	+0.331	+1.014	.003	<.001	2	10
UPPER_AERODIGESTIVE_TRACT	Protein stabilization →	+0.070	+1.229	<.001	<.001	3	9
STOMACH	Vacuolar transport →	+0.050	+0.933	.003	.001	3	9
UPPER_AERODIGESTIVE_TRACT	Regulation of tumor necrosis factor-mediated signaling pathway →	+0.079	+0.807	<.001	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,050 associations by consensus.

Negative regulation of autophagy by H2BS1 expression — BLOOD_Lymphoma

Explore this box plot interactively →