H2BC8

Across TCGA patient cohorts, H2BC8 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H2BC8-associated genes across cancer lineages are Paxillin, Rictor, and B-Raf. Each is linked with H2BC8 in more than 1 cancer types. Because this analysis shows association rather than direction, both H2BC8-to-partner and partner-to-H2BC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Paxillin grouped by H2BC8-low versus H2BC8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2BC8→partner) and Y-score (partner→H2BC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Paxillin →	-0.283	-3.169	.046	.020	3	1
UCEC	Rictor →	-0.614	-3.169	.048	.020	3	1
UCEC	B-Raf →	-0.524	-3.169	.007	.020	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Paxillin by H2BC8 expression — UCEC

Explore this box plot interactively →