H2BC8

Across TCGA pan-cancer cohorts, H2BC8 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of H2BC8’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where H2BC8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types H2BC8 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

LUAD, BLCA, and LIHC are the cancer types where H2BC8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in H2BC8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	All	+2.339	<.001	11	view →
BLCA	All	All	+2.378	<.001	9	view →
LIHC	Male	II,III,IV	+1.616	<.001	9	view →
LUSC	Female	All	+2.277	<.001	8	view →
HNSC	Male	All	+1.501	<.001	8	view →
BRCA	All	III,IV	+2.453	<.001	6	view →
UCEC	All	III,IV	+2.326	<.001	6	view →
KICH	All	All	−1.501	<.001	6	view →
STAD	All	All	+0.787	.005	4	view →
CHOL	All	All	+3.116	<.001	3	view →
ESCA	All	All	+1.612	.018	2	view →
PRAD	All	All	+1.248	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

H2BC8–LUAD

Open the LUAD breakdown →