H2BC7

Across TCGA cell cohorts, H2BC7 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,537 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible H2BC7-associated GO terms across cancer lineages are Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway, Positive regulation of signal transduction by p53 class mediator, and Viral transcription. Each is linked with H2BC7 in more than 7 cancer types. Because this analysis shows association rather than direction, both H2BC7-to-partner and partner-to-H2BC7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway grouped by H2BC7-low versus H2BC7-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (H2BC7→partner) and Y-score (partner→H2BC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway →	+0.128	+1.062	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Positive regulation of signal transduction by p53 class mediator →	+0.092	+0.811	<.001	<.001	3	8
LUNG_SCLC	Viral transcription →	+0.110	+0.805	.007	.002	3	7
LUNG_SCLC	Negative regulation of wound healing →	-0.079	-0.575	.007	.004	3	7
OVARY	Negative regulation of autophagy →	+0.049	+0.694	.003	.004	3	7
OVARY	Regulation of RNA splicing →	+0.081	+0.938	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,537 associations by consensus.

Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway by H2BC7 expression — OVARY

Explore this box plot interactively →