H2BC4

Across TCGA patient cohorts, H2BC4 mutation is significantly associated with the RNA expression of many other genes, with 102 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible H2BC4-associated genes across cancer lineages are MTND1P3, BNIP3P31, and RN7SL715P. Each is linked with H2BC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both H2BC4-to-partner and partner-to-H2BC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTND1P3 grouped by H2BC4-low versus H2BC4-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2BC4→partner) and Y-score (partner→H2BC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MTND1P3 →	+0.084	+4.855	<.001	<.001	3	2
LUSC	BNIP3P31 →	+0.178	+4.344	<.001	<.001	3	2
LUSC	RN7SL715P →	+0.093	+4.055	<.001	.001	3	2
HNSC	MIR548AD →	+0.598	+7.954	<.001	.008	3	2
HNSC	TTTY1 →	+0.079	+7.954	<.001	.008	3	1
HNSC	OR10R2 →	+0.069	+7.954	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 102 associations by consensus.

MTND1P3 by H2BC4 expression — LUSC

Explore this box plot interactively →