H2BC3

Across TCGA patient cohorts, H2BC3 mutation is significantly associated with the RNA expression of many other genes, with 646 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H2BC3-associated genes across cancer lineages are MIR4445, MIR7702, and CCDC43. Each is linked with H2BC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both H2BC3-to-partner and partner-to-H2BC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4445 grouped by H2BC3-low versus H2BC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2BC3→partner) and Y-score (partner→H2BC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR4445 →	+0.294	+5.308	<.001	.001	3	2
UCEC	MIR7702 →	+0.338	+4.890	<.001	.002	3	2
UCEC	CCDC43 →	+0.604	+3.354	.006	.005	3	1
UCEC	PRORY →	+0.035	+4.300	<.001	.005	3	1
UCEC	IRAK1 →	+1.010	+3.354	<.001	.005	3	1
UCEC	MRPL30 →	+0.538	+3.364	.006	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 646 associations by consensus.

MIR4445 by H2BC3 expression — UCEC

Explore this box plot interactively →