Across TCGA cell cohorts, H2BC21 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible H2BC21-associated genes across cancer lineages are OR10AG1, PABPC1L2A, and OR6M1. Each is linked with H2BC21 in more than 1 cancer types. Because this analysis shows association rather than direction, both H2BC21-to-partner and partner-to-H2BC21 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2BC21→partner) and Y-score (partner→H2BC21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR10AG1 →	+0.043	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	PABPC1L2A →	+0.045	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR6M1 →	+0.058	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR14A2 →	+0.022	+5.228	<.001	.005	3	1
LARGE_INTESTINE	ITGAD →	+0.015	+4.095	<.001	.009	3	1
LARGE_INTESTINE	BPIFB6 →	+0.025	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

H2BC21 survival (RNA) · tumor vs normal (RNA) · all H2BC21 data types