Across TCGA pan-cancer cohorts, H2BC21 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of H2BC21’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where H2BC21 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types H2BC21 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.
HNSC, LIHC, and BLCA are the cancer types where H2BC21 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in H2BC21 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.