H2BC1

Across TCGA pan-cancer cohorts, H2BC1 mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of H2BC1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where H2BC1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types H2BC1 is over-expressed in tumor.

LUAD and PDAC are the cancer types where H2BC1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in H2BC1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	+0.876	.003	3	view →
PDAC	All	All	+0.691	.012	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

H2BC1–LUAD

Open the LUAD breakdown →