H2BC1

Across TCGA pan-cancer cohorts, H2BC1 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated H2BC1 data layer compared with 1 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher H2BC1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated H2BC1 expression acts as an unfavorable survival marker, although some lineages such as KIRP and SCLC show a favorable association.

READ, KICH, and THCA are the cancer types where H2BC1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Tertile	All	0.217	0.828	<.001	90	view →
KICH	DFS	Tertile	All	0.081	0.904	<.001	90	view →
THCA	OS	Tertile	IV	0.579	0.986	<.001	72	view →
COAD	OS	Tertile	III,IV	0.201	0.799	<.001	54	view →
KIRP	OS	Tertile	III,IV	1.000	0.487	.019	37	view →
BLCA	DFS	Tertile	All	0.078	0.594	<.001	27	view →
PAAD	DFS	Tertile	III,IV	0.118	0.734	.014	18	view →
LUSC	OS	Tertile	All	0.659	0.781	.029	12	view →
LIHC	DFS	Median	All	0.483	0.578	.019	11	view →
SCLC	OS	Tertile	III,IV	1.000	0.578	.035	9	view →
SKCM	DFS	Tertile	III,IV	0.040	0.597	<.001	9	view →
SARC	OS	Tertile	All	0.604	0.846	.009	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

H2BC1–READ (OS)

Open the READ breakdown →